Our new paper has been published in Scientific Reports.
We compared the expression levels of miRNAs and genes of primary tumors from CRC patients, with and without metastasis, to identify metastasis-initiating miRNA-target regulations. We identified 516 metastasis-initiating miRNA-target regulations, including 17 miRNAs and 198 target genes. Our study will provide more convincing knowledge about the roles of miRNA-gene regulations that initiate liver metastasis in colorectal cancer.
Jongmin Lee, Hye Kyung Hong, Sheng-Bin Peng, Tae Won Kim, Woo Yong Lee, Seong Hyun Yun, Hee Cheol Kim, Jiangang Liu, Philip J. Ebert, Amit Aggarwal, Sungwon Jung & Yong Beom Cho. “Identifying metastasis-initiating miRNA-target regulations of colorectal cancer from expressional changes in primary tumors” Scientific Reports, 10:14919,2020.